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3.2.7 Other PD-related genes/proteins potentially associated with ferroptosis The absence of CISD1, an iron-rich outer mitochondrial membrane protein, triggers mitochondrial dysfunction alongside the depletion of striatal dopamine and TH, thus facilitating the advancement of PD and the worsening of its clinical manifestations (172)

However, this adaptive mechanism may not be sufficient to counteract the overwhelming oxidative burden caused by iron overload (83)

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