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This work suggests that HGF-MET may also protect from parthanatos, a form of caspase-independent regulated cell death occurring especially in neurons and driven by PARP1 hyperactivation (Galluzzi et al., 2018)

Pharmacological and/or dietary induction of the Nrf2/HO-1/NQO1 pathway may serve as a therapeutic strategy to prevent oxidative stress-induced damage in the peripheral vessels or the bloodbrain barrier in stroke [185]