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Dermatology, 2013, 228: 34-36

Melanotan II can cause a sudden increase in moles and freckles on your body, and its also associated with melanoma, an invasive skin cancer with a high risk of death

The lactam bridge between Asp5 and Lys10 side chains cyclises the heptapeptide backbone and constraining it into a compact, conformationally rigid structure that stabilises the receptor-binding pharmacophore conformation required for high-affinity MC3R and MC4R engagement