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Acyl-CoA synthase long-chain family member 4 (ACLS4) is a fatty acid activating an enzyme that catalyzes the esterification of long-chain PUFAs such as arachidonic (AA) and adre-noyl (AdA) to form PE, which is an integral component in the GPX4-dependent ferroptosis pathway [33, 34]

A Herxheimer reaction occurs when bacteria are killed during treatment, triggering an inflammatory response that temporarily worsens symptoms such as fatigue, pain, brain fog, or flu-like illness

Consequently, iron-reducing capacity was assigned a weight of 0.132, POD activity 0.122, and resveratrol content 0.119

doi:10.1016/j.cotox.2017.10.008