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After the activation of p38 and JNK in MAPK pathway, they can also enter the nucleus and upregulate the expression of related inflammatory cytokines, induce the expression of MMPs and downregulate TGF- expression, thus playing an important role in the UV-mediated photodamage [31, 32] (Fig

Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., & Kolega, Z

Thirdly, immune dysfunction may amplify infection risks from probiotics, hyperglycemia-altered microenvironments may reduce the efficiency of microbial colonization, and long-term safety of prolonged interventions lacks longitudinal follow-up data

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