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Tetsuya Hosaka 1 , Fumitaka Suzuki 1 , Mariko Kobayashi 1 , Shunichiro Fujiyama 1 , Yusuke Kawamura 1 , Hitomi Sezaki 2 , Norio Akuta 1 , Yoshiyuki Suzuki 1 , Satoshi Saitoh 1 , Yasuji Arase 1 , Kenji Ikeda 1 and Hiromitsu Kumada 1 , (1)Toranomon Hospital, (2)Toranomon Hospital, Tokyo, Japan Background: Long-term nucleos(t)ide analogues (NUCs) treatment improve the prognosis in chronic hepatitis B (CHB) patients