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Pharmacological considerations for treating neuroinflammation with curcumin in Alzheimers disease

Khan et al., 2016) (Figure 2)

CONCLUSIONS Together, this evidence suggests that oxidative stress and in particular disturbed glutathione metabolism are related to the pathogenesis of hypertension

GPX4 plays a pivotal role in regulating lipid peroxides within cells and the reduction in GSH and GPX4 that we demonstrate in the IB3-1 AECs following FAC and erastin treatment is likely responsible for the increased lipid peroxidation that we found, as evidenced by the increase in MDA and C11-BODIPY