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Disease mechanisms of C9orf72 repeat expansions

DeFoor MT, Dekker TJ

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Nicotinamide and Allopurinol Allopurinol is a drug widely used in the management of hyperuricemia and gout, with powerful antioxidant activities, being an inhibitor of the enzyme xanthine oxidase ( + ) precursor, which is a coenzyme involved in a number of metabolic pathways and in the balance of cell redox state ( in vitro study performed in cultured OFs from patients with GO, incubated with interferon (IFN-) and tumor necrosis factor (TNF-) in the presence of nicotinamide ( Pentoxifylline Pentoxifylline is an analog of the methylaxantine theobromine with anti-inflammatory and antioxidant properties ( Quercetin Quercetin is a member of the flavonoid family contained in vegetables and fruits, which assures an adequate intake with diet ( in vitro studies evaluated the possibility that quercetin may reduce the proliferation of OFs in GO