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Studies associate this state with lower mtDNA copy number and higher levels of mtDNA mutations in CD4+ T cells ( 6.2 Associating mtDNA integrity with comorbidities and disease progression Longitudinal studies are increasingly linking mtDNA integrity to the risk of developing non-AIDS-defining comorbidities, positioning mitochondrial decline as a central mechanism in HIV-associated accelerated aging

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The result is a profound reduction in appetite that most patients describe as simply not thinking about food anymore

[PubMed: 8122618] 216