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In Vivo Models Effects on Inflammatory Cytokines and NLRP3 Inflammasome Caspase-1 Signaling Tetracyclines significantly reduce the secretion of pro-inflammatory cytokines, including TNF-, IL-1, IL-6, and IL-8, thereby improving survival and lung injury in indirect models of ARDS [16, 19, 24]

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Clinical barriers and unresolved controversies The Nrf2 paradox and immunological ambiguity Despite an expanding body of descriptive evidence, the clinical translation of ROS-targeting therapies remains limited by several fundamental paradoxes and unresolved questions

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