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Many azoles seemingly perturb endocrine signaling by disrupting steroidogenesis by inhibiting CYP enzyme activities and can alter steroid hormone concentrations both in vitro and in vivo as reviewed by ( Prochloraz can inhibit steroidogenesis and antagonize the AR in vitro ( in vivo with testosterone output by fetal testis being reduced ( In utero exposure to prochloraz can affect the development of several androgen-sensitive tissues ( in utero exposure at dose between 25 and 150 mg/kg, yet significant effects on NR ( in vitro activities and may be the result of a mechanisms of effect yet to be appreciated or complex in vivo toxicokinetics

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These cells are favored due to their abundant availability and the straightforward process of isolation from fat tissue