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Model building and refinement The initial structure model of hTauT was computationally generated using AlphaFold3 (AlphaFold Protein Structure Database, #AF-P31641-F1) 58 and then fitted into the cryo-EM map using UCSF Chimera X 59 and rebuilt manually using Coot 60

By initiating treatment expeditiously after the initial diagnosis, we aim to capitalize on the window of opportunity to modulate the autoimmune response and promote thyroid regeneration effectively

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Metformin , the first-line drug treatment for type 2 diabetes, lowers elevated blood glucose in part by suppressing gluconeogenesis in the liver (McIntosh 2011