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L-NAME rats exhibited the moderate generalized irregularity in the diameter of blood vessels with moderate atrophy of the optic disc, faint presentation of the choroidal blood vessels appearing immediately, and these lesions (Figure 2, IN, IIN), and a rapid progress to the severe stage (Figure 3, AC

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Traditional swallowed forms have limited effectiveness due to digestive breakdown, but sublingual troches and liposomal formulations improve absorption significantly