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The detailed interrelationships and interdependencies between substances that damage the epithelial barrier, the intestinal microbiota, the immune system, the development of inflammation, changes in cell function and ultimately the development of diseases, often located distantly from the intestine, remain unclear

Key effects on gastrointestinal function include: Impaired absorption of fat-soluble vitamins Reduced ability to absorb iron from non-heme sources Potential for gastrointestinal disturbances due to iron overload Micronutrient Deficiencies Common in Thalassemia Thalassemia patients are more likely to lack certain nutrients, like vitamin B12

For most people, B12 and B Complex injections or drips are very safe and well-tolerated , especially when given in appropriate doses and by a trained professional

10.1038/ni1206