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This is the earliest direct biomolecular evidence of betel nut use in south-east Asia. We demonstrate that dental calculus can preserve chemical signatures of psychoactive plant use for millennia, even when conventional archaeological evidence is completely absent, added Dr Shannon Tushingham, the senior author, who is the associate curator of anthropology at the California Academy of Sciences

For non-survey years, we calibrated the realised prevalence scenario to trend lines that we fit to age-group specific prevalence rates in the survey years