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Several polyphenols have been shown to modulate sirtuin 1 signaling pathway and regulate key cell processes, such as cell cycle, DNA repair, protein aggregation, inflammation, and mitochondrial function [88]

The guanine and deoxyguanosine oxidation products 8-oxoG and its nucleotide 8-oxo-2-deoxyguanosine (8-oxodG) are ROS-mediated DNA lesions considered the most significant biomarkers for oxidative DNA damage (40)

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Anti-Inflammatory and Antioxidant Effects Chronic low-grade inflammation is a hallmark of both obesity and the weight loss process itself