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Curnock, R., Calcagni, A., Ballabio, A

Lauras B, Drevon B, Rolland MO, Teyssier G, Bovier-Lapierre M, Freycon F

Rational combinations, such as Ag or Cu for rapid load reduction, Zn for osteo-immunomodulation, and Ga for anti-biofilm pressure via iron mimicry, offer a coherent, non-antibiotic pathway to reduce implant-associated biofilm infections while restoring immune homeostasis Gas controlled-release antibacterial coatings Gasotransmitters such as nitric oxide (NO), hydrogen sulfide (HS), and carbon monoxide (CO) have recently emerged as promising non-antibiotic agents for combating implant-associated infections due to their dual antibacterial and immunomodulatory effects

The geroscience hypothesis proposes this principle but necessitates experimental testing