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It involves the decomposition of H 2 O 2 into water and monodehydroascorbate (MDHA) by ascorbate peroxidase (APX), the reduction of MDHA to ascorbate (AsA) or its disproportionation to dehydroascorbate (DHA) by MDHA reductase (MDHAR), and the reduction of DHA back to AsA by dehydroascorbate reductase (DHAR) using glutathione (GSH)

doi:10.1016/j.jad.2006.08.022 [cited 2021 Nov 24] 36

NAC's NMDA receptor modulation (via cystine-glutamate antiporter regulation in the nucleus accumbens) has demonstrated clinical efficacy in: OCD (obsessive-compulsive disorder): Lafleur et al

Such information will guide the design of in vitro and ex vivo models with relevant exposure concentrations and will assist animal models to reveal relevant molecular targets and cellular mechanisms of the individual components of kava ingredients