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Precisely how H4R and the release of these mediators are connectedeither directly or indirectlyas well as the identity of the H4R-bearing cell (discussed further below) remains to be determined

Distinctively, the cytological characteristic hallmarks of apoptotic cell death, including chromatin condensation and plasma membrane blebbing, as well as the morphological characteristics of necroptosis, i.e., the swelling of cytoplasmic organelles, are rarely observed during ferroptotic cell death (7,13)

Such dysregulation fosters a permissive environment for malignant transformation by altering gene expression networks essential for cellular growth control, apoptosis, and DNA repair