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Immunological analyses were supported in part by the Penn State Cancer Institute through the Clinical Correlative Immunology Laboratory (TDS, JPH)

By contrast, during oxidative stress, Nrf2 dissociates from Keap1, translocates to the nucleus, forms a heterodimer with small musculoaponeurotic fibrosarcoma oncogene homolog proteins and binds to ARE, thereby enhancing the transcription of antioxidant genes (6365)