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However, in recent years, there have been few further studies on the regulation of the PI3K/Akt pathway by LAM, and additional research is still needed to explore whether the path mediated by LAM can affect macrophage apoptosis by modulating other cytokines and influence host apoptosis by interacting with other cellular pathways

The activated NF-B then binds to a specific DNA binding domain and upregulates the corresponding antioxidant gene expression (e.g., SOD) (Morgan and Liu, 2011

Yap has a significant promoting effect on cancer progression, drug resistance and metastasis of NSCLC [126, 127]

Figure 3 Conclusion The authors showed that ROS promoted S-glutathionylation of FABP5 in macrophages under oxidative conditions