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In contrast, there is some evidence of an enhancement of the maximum absorption via intrinsic factor, by up to a factor of 2, when the vitamin B12 is accompanied by food, but this is not consistently observed and probably only applies when the food quantity and vitamin B12 dose are sufficient to slow the passage of the vitamin B12 through the small intestine enough (about three hours or more) to allow each intrinsic factor receptor to absorb two molecules of vitamin B12 from the oral dose rather than one

Usage Cited in: Brain Behav Immun

Early studies in obese individuals and animal models have shown it has potential to improve metabolic flexibility and support body fat loss, though further research is needed

It acts selectively on lipid metabolism, avoiding the broader hormonal effects seen with full growth hormone treatments