glutathione peroxidase neural excitability

glutathione peroxidase neural excitability Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator 4 (GPX4) | Molecular Neurobiology Dopamine-Derived Oxidative Stress in Attention-Deficit/Hyperactivity

Name: glutathione peroxidase neural excitability Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator 4 (GPX4) | Molecular Neurobiology Dopamine-Derived Oxidative Stress in Attention-Deficit/Hyperactivity
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Dopamine Derived Oxidative Stress in Attention Deficit Hyperactivity Disorder: A Narrative Review of Molecular Mechanisms, Neural Circuitry, and Therapeutic Implications Glutathione Peroxidase 1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities PMC Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice Xu 2023 The Journal of Physiology Wiley Online Library Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases PMC

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Here's the mechanism: the enzyme ALDH2 (aldehyde dehydrogenase 2) oxidises acetaldehyde into acetic acid, but this process requires adequate glutathione reserves to neutralise reactive oxygen species (ROS) generated during the reaction