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Polycaprolactone electrospun mesh conjugated with an MSC affinity peptide for MSC homing in vivo

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These effects were associated with increased nuclear factor erythroid 2-related factor 2 (Nrf2) gene expression, suggesting involvement of both antioxidant and anti-inflammatory mechanisms ( TLR4 signaling has been implicated in inflammation-induced immunopathogenesis during viral infection ( Network pharmacology and protein-protein interaction analyses have identified IL-6, TNF, IL-1B, prostaglandin endoperoxide synthase 2, and NF-B1 as core molecular targets of PYC, with Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment highlighting the IL-17 and TNF signaling pathways as key anti-inflammatory mechanisms