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Disturbances in the endoplasmic reticulum can be triggered by increased oxidative stress, deposition of saturated fatty acids, hypoxia, or other stimuli, which in turn cause the accumulation of unfolded proteins in the endoplasmic reticulum lumen that is filled with proteins, antioxidants, or essential metals

(1998) ADP-ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes

The docking analyses revealed that the positioning of the GSH-thiolate in relation to C-2 and O-3 of the docked substrates could enable an acidbase mechanism of dehydration or tautomerization, in which the GSH cofactor acts as a proton-relay system (Fig

Additionally, exposure of erythrocytes to heavy metals, pollutants, and xenobiotics triggers eryptosis through various mechanisms of cell death