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More recently, Xiong and his team found that impaired epoxyeicosatrienoic acid (EET) signaling can impede ATP release from astrocytes in the mPFC, inducing depressive-like behavior (Xiong et al., 2019)

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Furthermore, the compensatory hyperinsulinemia resulting from adipose dysfunction stimulates de novo lipogenesis in hepatocytes while simultaneously impairing muscle glucose uptake, creating a pathological metabolic state that propagates systemic insulin resistance (157)