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curculigine A (30 ) and curculigine D (31 ) and evaluated for anti-osteoporosis [57] hepatotoxicity effect on the human hepatic cell line HL-7702 and it was reported that it showed no positive effect [58]

Little solid scientific evidence exists to support claims for alternative therapy benefiting menopausal health

On the one hand, they can repair the integrity of the damaged intestinal barrier and promote the enrichment and metabolic activity of protective flora (such as Akkermansia and Lactobacillus ), thereby down-regulating the low-grade chronic inflammation in the whole body and local joints through the gut-joint axis. On the other hand, they can directly inhibit the iron-dependent lipid peroxidation cascade reaction in chondrocytes (such as regulating the GPX4, NRF2 pathways and the expression levels of proteins implicated in iron metabolism) to block or delay the ferroptosis of chondrocytes

In others, especially where traditional medicine is widely practiced, there may be greater trust in natural or plant-based antioxidants