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Wang T, Sternes PR, Guo X-K, Zhao H, Xu C, Xu H (2024) Autoimmune diseases exhibit shared alterations in the gut microbiota

Some of the reported causes are as follows: (1) the high lipophilicity of these compounds such that low solubility in water that limits their absorption, (2) hepatic first-pass metabolism, (3) rapid metabolism, (4) irregular pharmacokinetics, (5) their instability in the presence of gastric pH, and (6) the influence of temperature [76,162,163,164]

In light of these observations, two studies have attempted to administer GSH via inhalation to subjects with asthma

However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]