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Yang X, Lu M, Wang Y, Wang Y, Liu Z, Chen S

Chem Biol 15:234245 Yin Y, Seifert A, Chua JS, Maure J-F, Golebiowski F, Hay RT (2012) SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

Many of these pathways converge on key clinical targets like p53, Wnt/-catenin, ROS/JNK, NLRP3 inflammasomes, and PXR-driven drug metabolism, emphasizing SIRT1s central role in balancing stress responses and survival signals in liver cancer