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Additionally, disturbances in mitochondrial iron metabolism are strongly associated with ferroptosis ( Moreover, during ferroptosis, the generation of ROS can exacerbate lipid peroxidation, thereby establishing a harmful cycle that facilitates the onset of ferroptosis ( 2.1.2 Lipid peroxidation Lipid peroxidation reactions exacerbate the process of ferroptosis

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Antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase are essential for neutralising reactive oxygen species (ROS) [97, 98]