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Moreover, there is evidence of increased CD16 + monocytes in the blood of individuals with CD and these cells have been implicated as drivers of inflammation as they extravagate the blood vessels and enter the gut tissue [43, 47]

The cuprizone model is a widely-used toxin-induced multiple sclerosis model (Kipp, 2024

The i.p injection allows nanozymes to penetrate the systemic circulation, resulting in extensive distribution and possible neuroprotective effects across the body [137]