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Understanding the underlying mechanisms and triggers of hyperpigmentation is essential for selecting appropriate treatment approaches that address the root cause rather than merely masking symptoms

As a consequence, each daughter cell keeps same affinity with probability p sil = (1 ) + q sil , dies with probability p let = q let , or modifies affinity with probability p aa = q aa

Kajimura S, Aida K, Duan C: Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation