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Liangge San (LGS), a traditional Chinese herbal formulation for treating acute pathogen-induced syndromes of the upper and middle jiao, contains bioactive components including luteolin and wogonin that may ameliorate LPS-induced acute lung injury through multiple mechanisms

Because of the much stronger carbon-fluorine bonds relative to carbon-chlorine bonds, fluoromethylketones were expected to be poorer alkylating agents and should reduce the non-specific alkylation significantly compared to chloromethylketones

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The mechanism of this therapy is not fully understood, but it is known that there is an interference with pathological and physiological neural circuitry [79]