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People with lower CYP1A2 activity may generate reactive aflatoxin metabolites more slowly (could be a good thing), but they can still be vulnerable if downstream conjugation pathways (GSTs, UGTs) are also compromised.[ref] Related article: CYP1A2 Gene: Fast or Slow Caffeine Metabolizer and More CYP3A4 and aflatoxin G1 / other mycotoxins: CYP3A4 is involved in the metabolism of aflatoxin G1 and many other compounds, including medications

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Similar to proteasome inhibitors, efforts are needed to develop specific DUB inhibitors with greater therapeutic effects and less toxic side effects

Fish treated acutely with neomycin or gentamicin, and their associated controls, were allowed to recover in EM for 45 min prior to hair cell assessment