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Skin, being the largest organ of the human body, is composed of three main layers: Epidermis : Sublayers include stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and stratum basale

Although the mechanisms by which DUX4 exerts myotoxicity remain unclear, accumulating evidence has indicated that DUX4 induces oxidative stress, which plays an important role in FSHD pathogenesis (1, 2, 4, 14)

These include the ability to suppress or eliminate harmful bacteria, balance the intestinal microecology, promote digestion and nutrient absorption, improve the intestinal environment, stimulate immune cell function, and strengthen the bodys immune response ( 4.3.2 Mechanism of action in dry eye disease Recent studies have advanced our understanding of the ocular surface microbiota, identifying key bacterial groups such as Firmicutes (such as Staphylococcus and Streptococcus ), Actinomycetes (specifically Corynebacterium ), and Proteobacteria (including Acinetobacter and Pseudomonas )

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