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Furthermore, HIF-1 activation is closely associated with tumor migration and invasion, as it can upregulate matrix metalloproteinases (MMPs) and other proteins, facilitating extracellular matrix degradation and increasing tumor cells' invasive and metastatic potential (52)

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(PubMed) Jung ES, Kwon O, Lee SH, et al

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310 YamamotoH.ZhangS.MizushimaN

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