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FLSs, the dominant non-immune cells of the synovium, develop abnormal proliferative capacity and aggressive characteristics under oxidative stress conditions ( Figure 4 )

doi: 10.1016/j.intimp.2024.111940 Summary Keywords multi-omics, single-cell sequencing, glutathione metabolism, immunotherapy, prognostic model Citation Chi Y, Ma G, Liu Q, Xiang Y, Liu D and Du J (2025) Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma

The use of compounds that stimulate Sirtuin and AMPK modulators SIRT1/SIRT6 (e.g., resveratrol, NMN) has shown potential to restore mitochondrial biogenesis and attenuate OS in insulin-resistant tissues (Wang et al., 2023), although robust clinical trials are lacking