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Edaravone also was also shown to promote the antioxidant defense mechanisms by increasing Nrf2, GPx, SOD, HO-1, and NQO1 protein contents (Figure 3), attenuating the effects of traumatic brain injury [219]

However, CCL5, as a downstream effector molecule of GZMK, interacts with it and activates the ERK signaling pathway, thereby driving the proliferation, migration, and invasion of synovial fibroblasts, and inhibiting their apoptosis and ferroptosis, ultimately accelerating the progression of experimental rheumatoid arthritis (98)

Vitamin E inhibits the amplification of free radical reactions as an antioxidant that breaks down chains (45)