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As not all patients with FEP will be able to increase GSH in accordance with glutamate levels, we expected a reduction in the strength of correlation between the GSH and glutamate levels in patients compared with healthy controls (hypothesis 2)

Improvements in subscales of the Vineland Adaptive Behavior Scale, the Aberrant Behavior Checklist, the Autism Symptom Questionnaire and the Behavioral Assessment System for Children were significantly greater in the folinic acid group as compared with the placebo group

Moving forward, an individualised treatment of iron deficient patients might be preferably opted for, which requires a detailed diagnostic evaluation of iron deficiency and its origin by routine blood testing prior to iron supplementation

However, it was found that the presence of polymorphisms in the genes encoding this enzyme can contribute to an increased risk of CRC development in the case of interaction with other factors, such as diet or smoking [33]