In this study, we aimed to assess the protective effects of the tetrapeptide Epitalon in an in vitro model of DR using an HG-injured ARPE-19 cell line
The researchers proposed that the senolytic effect observed in these cells is attributable not only to the disruption of the PI3K/AKT pathway but also to interference with the ERK/MEP pathway, which plays a crucial role in regulating inflammation and resistance to apoptosis [123]
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PMID 34877934
