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Dysregulated NLRP3 produces pro-inflammatory cytokines, IL-1 and IL-18, which serve to exacerbate myocardial damage initiating widespread inflammation within the cardiac tissue The activation of the NLRP3 inflammasome is related to several high-risk factors of DCM such as hyperlipidaemia, diabetes, obesity and hyperhomocysteinemia (100)

Topical GSH can be used alongside mild pigment inhibitors, such as arbutin or tranexamic acid

Widespread siRNA off-target transcript silencing mediated by seed region sequence complementarity