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To further strengthen the contribution of OS in ALS, an increase in the level of several proteins oxidatively modified and consequently inactivated has been found in SOD1 G93A transgenic mice and correlated with SOD1 mutation: such proteins are SOD1 itself, translationally controlled tumor protein (TCTP, which normally processes calcium binding activity and acts as a cytoprotective factor), and ubiquitin carboxyl-terminal hydrolase isoenzyme L1 (UCH-L1, which plays an important role in the ubiquitin-proteasome system, UPS)

Pathogen proliferation drives the secretion of a toxin cocktail (-toxin, perfringolysin O, and 2-toxin) that disrupts the abomasal mucosal barrier, which triggers necrosis, hemorrhage, and intramural gas accumulation and ultimately leads to severe structural degradation of the abomasal wall 70,71