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Graphic abstract Access this article Similar content being viewed by others References Millan JL (2006) Mammalian alkaline phosphatases: from biology to applications in medicine and biotechnology

This pathway contributes to both the development and exacerbation of asthma by mediating the release of pro-inflammatory cytokines such as IL1 and IL18, which are critical in the pathogenesis of severe steroid-resistant asthma (SSRA) and other asthma phenotypes [148, 149]