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The study found that the combined glucosamine-chondroitin group showed a statistically significant reduction in joint-space narrowing compared with placebo, indicating a structural benefit to joint integrity in a clinical population

In inflammatory diseases, ROS formation increases the production of intracellular advanced glycation end products, and activation of protein kinase C pathways occurs, leading to the activation of inflammatory signals, such as the NF-B pathway, p38 mitogen-activated protein kinase (p38MAPK), Jun N-terminal kinases (JNK), and ER stress

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