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Although LMNA (WT) has no differences to non-transgenic AB(WT) control, the LMNA mutant transgenic fish, particularly those with LMNA (L35P), LMNA (E358K), LMNA (R453W), and LMNA (A539V) variants, displayed significantly reduced muscle fiber diameters compared to LMNA (WT) group

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10.1016/j.expneurol.2010.02.006 26 BurgessJ.FerdousiM.GosalD.BoonC.MatsumotoK.MarshallA.et al (2021)

Firstly, we conducted an MR analysis utilizing two independent samples, employing genetic variants as proxies for possibly altered exposures while controlling for potential confounding factors that could distort observational association results