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In in vitro maturation (IVM) cultures, the addition of Necrostatin-1 significantly increased the expression of GDF9, Mad2, and Bcl-2 in immature oocytes in mice and prevented oxidative stress-mediated deterioration of oocyte quality (Tsui et al., 2017)

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Inflamed gastrointestinal lining will impair nutrient and thyroid absorption, thus leading to nutrient deficiencies and possibly even thyroid hormone deficiency due to impaired absorption