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Cell Metab 37 , 857869 (2025)

LINC01116 promotes doxorubicin resistance in osteosarcoma by epigenetically silencing miR-424-5p and inducing epithelial-mesenchymal transition

The increased production of endothelin-1 and decreased production of nitric oxide in senescent endothelial cells lead to vascular inflammation and impaired vasodilation, compromise vascular endothelial integrity, and lead to vascular aging and atherosclerosis