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Likewise, the overexpression of adhesion molecules like ICAM-4 and CD36 is associated with the severity of vascular problems in sickle cell aneamia and malaria, and their monitoring may offer clinicians important metrics for evaluating disease progression and treatment effectiveness

This correlation was strengthened when not including the six patients with an abnormal cortisol pattern (4) and bone marrow infiltration (2) (r = 0.66