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Interactions between TLR1/6 and the S-protein may participate in immunopathology as a result of unregulated TLR activation (Kawasaki and Kawai, 2014

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72 In chronic hepatitis B patients, those achieving functional cure have a higher abundance of butyrate-producing bacteria in their gut, and in vitro experiments confirmed that butyrate can directly inhibit HBsAg production in HBV-infected cells, revealing the potential role of SCFAs in antiviral immunity