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In the aortas of patients with AD, the levels of iron-death-associated molecules, such as transferrin receptor (TFR), Heme oxygenase-1 (HO-1), and ferritin, were increased, while the levels of iron-death-regulating proteins, including SLC7A11, GPX4, and FSP1, were decreased (Figure 1) ( FIGURE 1 This article aims to explore the potential connections and research significance of AD and ferroptosis by systematically reviewing the pathophysiological mechanisms of AD, as well as the characteristics of ferroptosis and its role in cardiovascular diseases

Trained immunity: innate immunity's memory and bone metabolic regulation Trained immunity refers to the enhanced response capacity acquired by innate immune cells (e.g., macrophages, monocytes) following initial exposure to pathogens or inflammatory stimuli

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